Experimental Studies on the effects of chlorpyrifos on Rats II. Histochemical changes

• Ibrahim S. H.. El-durssi

  Zoology Department / College of science / Omar El-Mukhtar University

  Author

• Ifdial I. O. El-Awami

  Faculty of Agriculture, Plant Protection Department, Omar Almukhtar University, El-Bieda-Libya

  Author

• Ghyath mahmoud

  College of veterinary medicine/Omar El-Mukhtar University

  Author

• Fahim A. Benkhaial

  Food technology department / college of agriculture / Omar El-Mukhtar University

  Author

This Study performed to investigate the effect of Chlorpyrifos (one of the most used insecticides)on certain organs in  rats .

The experimental animals were 110 male rats and were divided into four groups: the first group was used to determine the median lethal dose (LD₅₀) which appeared to be equal to (81.2)mg/Kg B.W.  While the second group of rats received an oral daily doses of 1/10 LD₅₀. The third and fourth groups of rats were administered single oral dose of 1/10 LD₅₀ and 1/30 LD₅₀ respectively.

Although histochemical investigation revealed that the epithelial cells of the intestine, liver biliary system and kidney’s tubules both in control and experimental rats contained a mixture of acid and neutral mucopolysaccharidse. This reaction matching the histochemistry of both the mast cells and goblet cells in control and experimental rats.

ناثرة محمد علي النعيمي (1989) ، التغيرات الكيمياوية النسيجية للأكياس العدرية في الجرذان المعرضة لجرع مختلفة من أشعة كاما . أطروحة ماجستير – كلية الطب البيطري . جامعة بغداد .

إبراهيم سالم حسين الدرسي (2005) ، التغيرات المرضية والنسيجية الكيمياوية الناتجة عن تجريع مبيد الكلوربايروفوس (الدورسبان) في الجرذان . أطروحة ماجستير – قسم الحيوان كلية العلوم – جامعة عمر المختار .

El- Culling, C. F. A. (1985). Handbook of Histopathological techniques. 5th. . Ed. Butterworth. London.

Mahmoud, G. S. (1979).Ovine Bronchopulmonary Globule Leukocytes. Ph. D. Thesis. Glsgow Univ. (U K).

Mahmoud, G. S. (1982). Ovine Bronchopulmonary Globule Leukocytes. I. Morphological and cytochemical studies .

Zbl. Vet. Med. C. Anat. Histol. Embryol . 11, 205-212.

Mahmoud, G. S. (1989). Histochemical alterations in the wall of hydated cysts in mice experimentally infected with the larval stage of Echinococcus granulosus exposed to various doses of gamma rays. J. Coll. Vet. Med. 1. 3.

Mahmoud, G. S. (1990/a). Pathological and Histochemical changes in the respiratory tract of Camel naturally infected with hydated cysts. Ibn-Al- Haithem. J.

Mahmoud, G. S. (1990/b). Pathological and Histochemical changes in the biliary system of cattle naturally infected with, Gigantocotyle explanatum. Iraq. Vet. Med. J. 14.

Mahmoud, G. S. (1990/c). Pathological and Histochemical changes in the biliary system of buffolloes naturally infected with chconic fascioliasis, Gigantocotyle explanatum. Iraq. Vet. Med. J. 14.

Pears, A. G. E. (1968). Histochemistry, Theoretical and Applied. 3rd . Ed. Churchill Livingstone. London.

Spicer, S. S. (1960). A correlative study of the Histochemical properties of rodent acid mucopolysaccharides. J. Histochem. Cytochem. 8:18-35.

Spicer,S. S. (1963). Histochemical properties of mucopolysaccharides and basic protein in mast cells. Annals of the New York Academy of Sciences. 103: 322-324.

• PDF (Arabic)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright of the articles Published by Almukhtar Journal of Science (MJSc) is retained by the author(s), who grant MJSc a license to publish the article. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors and cite MJSc as the original publisher. Also, they accept the article remains published by the MJSc website (except in the occasion of a retraction of the article).