Experimental Studies on the effects of chlorpyrifos on Rats V. mast cells and globule leukocytes

• Ibrahim S. H.. El-durssi

  Zoology Department / College of science / Omar El-Mukhtar University

  Author

• I. O. El-Awami

  College of agriculture / Omar El-Mukhtar University, P.O. Box. 919.

  Author

• Ghyath mahmoud

  College of veterinary medicine/Omar El-Mukhtar University

  Author

• Rafi M. El-Kaseh

  College of veterinary medicine/Omar El-Mukhtar University

  Author

This Study performed to investigate the effects of Chlorpyrifos (one of the most used insecticides)on certain organs of rats .

Thus a total of  110 male rats were used and experiment ally divided into four groups: the first group was used to determine the median lethal dose (LD₅₀) which appeared to be equal to 81.2 mg/Kg B.W.  While the second group of rats received an oral daily doses of 1/10 LD₅₀ . The third and fourth groups of rats  were administered a single oral dose of 1/10 and 1/30 LD₅₀ respectively.

The globule leukocytes were recognized as a cell with specific morphological character which appeared in the epithelia of the mucous membrane of lung and intestine under the influence of chlorpyrifos administration.

The Histochemical studies carried out   indicated that the mucopolysaccharides in both GL and MC granules were a mixture of neutral and acid sulphatedmucopolysaccharide.

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