Experimental Studies on the effects of chlorpyrifos on Rats IV. Biochemical changes in level of certain enzymes
DOI:
https://doi.org/10.54172/mjsc.v14i1.681Abstract
This Study performed to investigate the effect of Chlorpyrifos (one of the most used insecticides) on certain enzymes in rats .
Thus a total of 110 male rats were used and experimentally divided into four groups: the first group was used to determine the median lethal dose (LD50) which appeared to be equal to 81.2 mg/Kg B.W. While the second group of rats received an oral daily doses of 1/10 LD50 . The third and fourth groups of rats were administered a single oral dose of 1/10 and 1/30 LD50 respectively.
Biochemical investigations revealed an increase in the level of certain enzymes such as : the alkaline phosphatase (ALP), glutamic oxalic acetic transaminase (GOT), glutamic pyruvic transaminase( GPT), creatine kinase (CK) and lactic dehydrogenase (LDH).
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