Deltamethrin -induced deterioration in reproductive performance of male rabbits: Protective role of vitamin B9

Amani. M. M.  Salem; Fayrouz A.  Khaled; Mardia R. Farja

doi:10.54172/esmsc072

Authors

Amani. M. M. Salem Department of Biomedical Science, Faculty of Pharmacy, Omar Al-Mokhtar University, Al-Bayda, Libya Author
Fayrouz A. Khaled 2Department of Chemistry, Faculty of Science, Omar Al-Mokhtar University, Al-Bayda, Libya Author
Mardia R. Farja 2Department of Chemistry, Faculty of Science, Omar Al-Mokhtar University, Al-Bayda, Libya Author

DOI:

https://doi.org/10.54172/esmsc072

Keywords:

: Deltamethrin, reproductive performance, vitamin B9 and rabbits.

Abstract

Deltamethrin (DLM) is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. Vitamin B9 referred to folic acid identified as a member of co-factors implicated in the metabolism and cellular processes of single carbon such as biosynthesizes of purine, thymidylate, and methionine. Therefore, this study aimed at elucidating the protective effects of V.B9 against the reproductive toxicity of DLM in male rabbits. Five rabbits per group were assigned to 1 of 4 treatment groups: control; DLM (1.28 mg/kg); V.B9 (5mg/kg) DLM (1.28 mg/kg bw) plus V.B9 (5 mg/kg bw). Results showed that live body weight (LBW), testes relative weight (RTW), and serum testosterone were significantly reduced (P<0.05) by treatment with DLM, also decreased (P<0.05) ejaculate volume, sperm concentration, total sperm output, sperm motility index, semen initial fructose concentration and TBARS. The negative effects of DLM on semen characteristics were dose-dependent. Treatment with V.B9 increased (P<0.05) LBW, RTW and serum testosterone concentration, improved semen characteristics, and alleviated the negative effects of DLM treatment increased (P<0.05) the numbers of abnormal and dead sperms in a dose-dependent manner. Results demonstrated the beneficial influences of V.B9 in reducing the negative effects of DLM on the production and reproduction of male rabbits.

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