Red Cell Distribution Width and Respiratory Diseases in Tobruk Pediatric Intensive Care Unit
- Authors
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Nasren Gamal Saleh Alfraik Alfraik
Faculty of Medicine, Pediatric Department, Tobruck University, Tobruck, Libya..Author
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- Keywords:
- Red Cell Distribution Width, Respiratory Disease, Pediatric ICU
- Abstract
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The red blood cell distribution width (RDW) is a simple and inexpensive parameter, which reflects the degree of heterogeneity of erythrocyte volume. This retrospective study aimed to detect the correlation between RDW and respiratory diseases and analyzed all patients admitted to the Pediatric Intensive Care Unit (PICU) at Tobruk Medical Center between January 2017 and January 2019. All patients below 16 years old with an available baseline RDW value on admission to PICU and had had a respiratory disease and needed oxygen therapy were eligible for inclusion. Of the 76 patients studied, 36.8% had elevated RDW. The median age was 97.5 days old, 60.5% were male, and 39.4% females. All patients were Libyan and 97.4% from Tobruk. Causes of admission were 52.6% bronchopneumonia, 29% acute broncholitis, 10.5% aspiration pneumonia, 5.3% bronchial asthma, and CHD with apnea were 2.7%. We noted a respiratory retraction in most of the cases, grunting and retraction in 35%, and cyanosis in 28% of cases. Reported complications of this study were sepsis 41%, aspiration 24%, pneumothorax 10.5%, convulsion 9%, apnea 8%, pleural effusion 7% and renal failure 1%. 62% of our patients had pulmonary infiltration on chest x-ray. Regarding the route of oxygen therapy, 60.5% were treated with nasal prongs, 38% with masks, and 1.3% needed a mechanical ventilator. 29% of patients received steroids. The RDW mean was 14.499 and there were significant correlations between RDW and signs of respiratory distress, length of hospital stay, and duration of oxygen therapy. 98% of our patients were discharged. We conclude there is a strong correlation between RDW and respiratory diseases as pneumonia, acute broncholitis and we recommend farther studies to study the correlation between RDW and other organ diseases in the pediatric age group.
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- References
-
Allen, L.A., Felker, G.M., Mehra, M.R., Chiong, J.R., Dunlap, S.H., Ghali, J.K., et al. (2010).
Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. J Card Fail. 16:230–8.
Bessman, J. D., Hurley, E.L (1983). Groves MR. Nondiscrete heterogeneity of human erythrocytes: comparison of Coulter-principle flow cytometry and Soret-hemoglobinometry image analysis. Cytometry; 3:292–295.
Bujak, K., Wasilewski, J., Osadnik, T., Jonczyk, S., Kołodziejska, A., Gierlotka, M., et al. (2015). The Prognostic Role of Red Blood Cell
Distribution Width in Coronary Artery Disease: A Review of the Pathophysiology. Dis Markers. 824624.
Fontana, V., Spadaro, S., Bond, O., Cavicchi, F.Z., Annoni, F., Donadello, K., et al. (2017). No relationship between red blood cell distribution width and microcirculatory alterations in septic patients.
Grant, B.J.B., Kudalkar, D.P., Muti. P., McCann, S.E., Trevisan, M., Freudenheim, J.L., et al. (2003). Relation between lung function and RBC distribution width in a population-based study. Chest. 124:494.
Hunziker, S., Celi, L.A., Lee, J., Howell, M.D. (2012). Red cell distribution width improves the simplified acute physiology score for risk prediction in unselected critically ill patients. Crit Care.16:R89.
Ku, N.S., Kim, H., Oh, H.J., Kim, Y.C., Kim, M.H., Song, J.E., et al. (2012). Red cell distribution width is an independent predictor of mortality in patients with Gram-negative bacteremia. Shock. 38: 123–127.
Lippi, G., Targher, G., Montagnana, M., Salvagno, G.L., Zoppini, G., Guidi, G.C. (2009). Relation between red cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 133: 628–632.
Nagakumar, P., Doull, I. (2011). Current therapy for bronchiolitis. Arch Dis Child. 97: 827-830.
Otero, T.M., Canales, C., Yeh, D.D., Hou, P.C., Belcher, D.M., Quraishi, S.A. (2016). Elevated red cell distribution width at initiation of critical care is associated with mortality in surgical Intensive Care Unit patients. J Crit Care.34:7–11.
Said, Q.S., Spinella, P.C., Hartman, M.E., Steffen, K.M., Jackups, R., Holubkov, R. (2017). RBC Distribution Width: Biomarker for Red Cell Dysfunction and Critical Illness Outcome?. Pediatr Crit Care Med. 18:134–142.
Sincer, I., Zorlu, A., Yilmaz, M.B., Dogan, O.T., Ege, M.R., Amioglu, G., et al.(2012).Relationship between red cell distribution width and right ventricular dysfunction in patients with chronic obstructive pulmonary disease. Heart Lung. 41:238–243.
Tom, S., Jozef, J.De, D.,Walter, V., and Philippe, G. J. (2017). Red cell distribution width (RDW) as a biomarker for respiratory failure in a pediatric ICU. J Inflamm (Lond).14: 12.
Wang, F., Pan, W., Pan, S., Ge, J., Wang, S., Chen, M. (2011). Red cell distribution width as a novel predictor of mortality in ICU patients. Ann Med. 43:40–6.
Wang, N.S. (1998). Anatomy of the pleura. Clin Chest Med. Jun; 19(2):229-40.
Yčas, J.W., Horrow, J.C., Horne, B.D. (2015). Persistent increase in red cell size distribution width after acute diseases: A biomarker of hypoxemia?. Clin Chim Acta. 448:107–117.
Zhang, Z., Xu, X., Ni, H., Deng, H. (2013). Red cell distribution width is associated with hospital mortality in unselected critically ill patients. J Thorac Dis.5:730–6.
Zorc, J.J., Hall, C.B. (2010) Bronchiolitis: recent evidence on diagnosis and management. Pediatrics. 125: 342-349
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