The incidence Of Paget’s disease of the breast In Benghazi- Libya (During a period of 19 years)
- Authors
-
-
Tawfik Abuzalout
Department of Surgery, Faculty of Medicine, Benghazi University, Benghazi, LibyaAuthor -
Hasan I. Fadel Saad
Department of Surgery, Faculty of Medicine, Omar Al Mukhtar University, El Bayda, LibyaAuthor -
Salah Taktuk
Department of Surgery, Faculty of Medicine, Omar Al Mukhtar University, El Bayda, LibyaAuthor
-
- Keywords:
- Paget’s disease, eczema, breast carcinoma
- Abstract
-
Dermatoses of the nipple and areola are rare. The Paget's disease is a common dermatosis, which is presented in the form of a well-demarcated erythematous area, sometimes erosive, oozing or hyperkeratotic. Because the condition may be confused with benign diseases of the nipple, treatment is frequently delayed. The study aimed to highlight the incidence and make a clinical assessment of patients with Paget’s disease of the breast in the eastern part of Libya. The Medical records and histopathological reports of all patients attended the breast clinic in 7th October Hospital in the period from June 1990 till December 2008 were collected and reviewed retrospectively. Demography, clinical features, and biopsy results were noted. The results: The total number of patients who had breast cancer was 897, from which Paget’s disease was diagnosed in 19 patients (2.1%). Mean age at presentation was 57.3 years, and all of them were Women. Eczema of the nipple-areola complex and palpable mass occurred in (63.1% and 42.1%) respectively. The metastatic axillary lymphadenopathy at time of presentation were found in 36.8%. We conclude that Paget’s disease is serious but commonly misdiagnosed. A thorough history and physical examination are important for every patient who is presented with skin and/or nipple changes of the breast, and physicians should maintain a high index of suspicion for Paget’s disease of the breast.
- Downloads
-
Download data is not yet available.
- References
-
Caliskan, M., Gatti, G., Sosnovskikh, I., Rotmensz, N., Botteri, E., Musmeci, S., Luini, A. (2008). Paget’s disease of the breast: the experience of the European Institute of Oncology and review of the literature. Breast cancer research and treatment, 112(3), 513.
Chaudary, M. A., Millis, R. R., Lane, E. B., & Miller, N. A. (1986). Paget's disease of the nipple: a ten year review including clinical, pathological, and immunohistochemical findings. Breast cancer research and treatment, 8(2), 139-146.
Dixon, A., Galea, M., Ellis, I., Elston, C., & Blamey, R. (1991). Paget's disease of the nipple. British journal of surgery, 78(6), 722-723.
Gupta, S., Khanna, N., Khanna, S., & Gupta, S. (1983). Paget's disease of the male breast: a clinicopathologic study and a collective review. Journal of surgical oncology, 22(3), 151-156.
Harris, J. R., Lippman, M. E., Osborne, C. K., & Morrow, M. (2009). Diseases of the Breast: Lippincott Williams & Wilkins.
Kanitakis, J. (2007). Mammary and extramammary Paget's disease. Journal of the European Academy of Dermatology and Venereology, 21(5), 581-590.
Lancer, H. A., & Moschella, S. L. (1982). Paget's disease of the male breast. Journal of the American Academy of Dermatology, 7(3), 393-396.
Laronga, C., Hasson, D., Hoover, S., Cox, J., Cantor, A., Cox, C., & Carter, W. B. (2006). Paget’s disease in the era of sentinel lymph node biopsy. The American journal of surgery, 192(4), 481-483.
Lever, W. (1983). Schaumburg-Lever G. Histopathology of the skin. JB Lippincott, Philadelphia, 7, 620-622.
Maier, W., Rosemond, G., Harasym Jr, E., Al-Saleem, T., Tassoni, E., & Schor, S. (1969). Paget's disease in the female breast. Surgery, gynecology & obstetrics, 128(6), 1253.
Marshall, J. K., Griffith, K. A., Haffty, B. G., Solin, L. J., Vicini, F. A., McCormick, B., Pierce, L. J. (2003). Conservative management of Paget disease of the breast with radiotherapy: 10‐and 15‐year results. Cancer: Interdisciplinary International Journal of the American Cancer Society, 97(9), 2142-2149.
Nance FC, D. D., Welsh RA, Becker WF. (1970). Paget’s disease of the breast Ann surg, 171:864-177
Nehme, A. (1976). Paget's disease of the male breast: a collective review and case report. The American surgeon, 42(4), 289-295.
Paget, J. (1874). On disease of the mammary areola preceding cancer of the mammary gland. St. Bartholowmew. Hospital Reports, 10, 87-89.
Paone, J. F., & Baker, R. R. (1981). Pathogenesis and treatment of Paget's disease of the breast. Cancer, 48(3), 825-829.
Sakorafas, G., Blanchard, K., Sarr, M., & Farley, D. (2001). Paget’s disease of the breast. Cancer treatment reviews, 27(1), 9-18.
Satiani, B., Powell, R. W., & Mathews, W. H. (1977). Paget disease of the male breast. Archives of surgery, 112(5), 587-592.
Sheen‐Chen, S. M., Chen, H. S., Chen, W. J., Eng, H. L., Sheen, C. W., & Chou, F. F. (2001). Paget disease of the breast—an easily overlooked disease? Journal of surgical oncology, 76(4), 261-265.
Siponen, E., Hukkinen, K., Heikkilä, P., Joensuu, H., & Leidenius, M. (2010). Surgical treatment in Paget's disease of the breast. The American Journal of Surgery, 200(2), 241-246.
Sukumvanich, P., Bentrem, D., Cody III, H., Brogi, E., Fey, J., Borgen, P., & Gemignani, M. (2007). The role of sentinel lymph node biopsy in Paget’s disease of the breast. Annals of surgical oncology, 14(3), 1020-1023.
- Downloads
- Published
- 2026-05-03
- Issue
- Vol. 34 No. 1 (2019)
- Section
- Articles
- License
-

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright of the articles Published by Almukhtar Journal of Science (MJSc) is retained by the author(s), who grant MJSc a license to publish the article. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors and cite MJSc as the original publisher. Also, they accept the article remains published by the MJSc website (except in the occasion of a retraction of the article).
How to Cite
Most read articles by the same author(s)
- Hasan I. Fadel Saad, Tawfik Abuzalout, Naser Musbah, Ahmed Farag, The Outcomes of Management of Necrotizing Soft Tissue- Infections in Lower Limbs of Diabetic Patients , Al-Mukhtar Journal of Sciences: Vol. 34 No. 1 (2019)
- Naser Musbah, Hasan I. Fadel Saad, Salma Saleh Mohamed, Safety and Effectiveness of Total Thyroidectomy for Benign Multinodular Goitre , Al-Mukhtar Journal of Sciences: Vol. 34 No. 4 (2019)
- Hasan I. Fadel Saad, Mustafa Noom , Khalid Shnab, Abdel Magid El Osta, A Comparative Analysis of the Outcomes of Carotid Stenting and Carotid Endarterectomy in the Management of Carotid Stenosis , Al-Mukhtar Journal of Sciences: Vol. 34 No. 4 (2019)
Similar Articles
- Heba. Shareaf , Marfoua. S. Ali, Fayourz. A. Kahald, Prevalence and Analytic Study of Diabetic Patients in Al-Bayda, Libya , Al-Mukhtar Journal of Sciences: Vol. 32 No. 2 (2017)
- Nura I. Al-Zail, Antioxidant Activity of Lipoic Acid on Cyclosporine A-Induced Physiological Changes to the Kidneys in Male Albino Rats , Al-Mukhtar Journal of Sciences: Vol. 32 No. 1 (2017)
- Fathi M. Ali, Abdulsalam M. A. Aboelhaj, Waheeda R. Ali , Comparative Study of Immunization of White Mice Cells Against Hydatid Cysts Using Excretion/Secretion and Cyst Fluid Antigens II: Fluctuation in average percentage of Leukocytes , Al-Mukhtar Journal of Sciences: Vol. 21 No. 1 (2008): Special issue
- Rabya A. Lahme, Morris Angela, Simon Curling, Ormondroyd. Graham., Davey L. Jones, Prysor A. Williams, Effectiveness of a wool based packaging system on the abundance of surface spoilage microorganisms on fresh meat , Al-Mukhtar Journal of Sciences: Vol. 31 No. 1 (2016)
- Azza s. Abdelkafe, Muftah A. Nasib, Dermatophytosis in Al-Gabal Al-Akhader , Al-Mukhtar Journal of Sciences: Vol. 27 No. 1 (2012)
- Khalid.H. Saad, Asgad Abdulgabar, A study of the effeect of some physiological and Environmental Factors on myocardial infarction , Al-Mukhtar Journal of Sciences: Vol. 22 No. 1 (2009)
- Nagia A. S. Abdalsalam, Safia Hazawy , Hamzah Othman , Study on some hemato-biochemical changes associated with Babesia Bovine in cattle of El-Wisata -Libya , Al-Mukhtar Journal of Sciences: Vol. 34 No. 4 (2019)
- N.S. Abdallah, Isolation and Pathogenicity Test for Pathogenic Fungi Carried on Some Chickpea Cultivars Growing at Al-Jabal Al-Akhdar , Al-Mukhtar Journal of Sciences: Vol. 13 No. 1 (2006)
- Hashmi A. Agleyo, The First Discovery of the Tracheal mire Acarapis woodi in lonybee in Al-Jabal Al-Akhdar , Al-Mukhtar Journal of Sciences: Vol. 11 No. 1 (2004)
- Eabaas Ealaywi Alnaasir, Adib Dawud Salyman Kharufa, Study of the effect of feeding on the specifications slaughtered goat , Al-Mukhtar Journal of Sciences: Vol. 3 No. 1 (1996)
You may also start an advanced similarity search for this article.











