Protective role of selenium against diclofenac sodium induce nephrotoxicity in female rats
DOI:
https://doi.org/10.54172/v7e77b21Keywords:
selenium, diclofenac sodium, Histopathological, kidney, female ratAbstract
Selenium is an essential trace mineral found in soil, water, and some foods. It increases antioxidant effects in the body. Diclofenac sodium is one of the world's most commonly prescribed nonsteroidal anti-inflammatory drugs (NSAIDs). This study aimed to evaluate the histological changes induced by diclofenac sodium on the kidney of adult female rat and evaluating the possible ameliorative role of selenium. Healthy female rat 4 month old weighting 140-235g were divided equally into four groups. The first group was received only distilled water and considered as control group. The second group animals were received selenium at a dose of 0.25 mg/kg b/w by oral gavage daily for 21 days. Third group were receive diclofenac sodium at dose of 10mg/kg b/w by oral gavage daily for 14 days. And the fourth group the animals were given same dose of selenium for 7 days, during the next two weeks, animals given same dose of diclofenac sodium. Histological examinations revealed that administration of diclofenac sodium only exhibited marked glomerular and tubular lesion included vacuolization and swelling the lining epithelium of tubules, inflammatory cells infiltration and hemorrhage in the interstitial tissue, necrotic or desquamation lining epithelium in the luminal tubules, intratubular esinophilic casts in some renal tubules, completely obscured or stenosis urinary space of renal corpuscles, shrinkage glomeruli of some renal corpuscles with widening urinary space, many glomeruli appeared with less cellularily, dilation and congestion blood vessels. In contrast administration of selenium along with diclofenac sodium induced ameliorating change in renal tissue of diclofenac sodium intoxicated rat.
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