Detection the incidence of Rota virus infection among children under eight years presenting with diarrhea

Ilham. O. A. Abdraba; Ebtisam M. Abdurabbah; Salema R. M. Qowaider; Marfoua. S. Ali

doi:10.54172/yr111v46

Authors

Ilham. O. A. Abdraba Medical Microbiology and Immunology Department, Faculty of Medicine, Omar Al-Mukhtar University, El-Beyda, Libya Author
Ebtisam M. Abdurabbah Zoology Department, Faculty of Science, Omar Al-Mukhtar University, El-Beyda, Libya Author
Salema R. M. Qowaider Medical Microbiology and Immunology Department, Faculty of Medicine, Omar Al-Mukhtar University, El-Beyda, Libya Author
Marfoua. S. Ali Zoology Department, Faculty of Science, Omar Al-Mukhtar University, El-Beyda, Libya Author

DOI:

https://doi.org/10.54172/yr111v46

Keywords:

Rota virus, Gastroenteritis, age, male, female

Abstract

Acute diarrhea is a major cause of death worldwide in children and neonates. Rota virus is the most common cause of severe pediatric gastroenteritis and diarrhea, especially in those countries that have not launched a Rota virus immunization program. The primary aim of the study was to detect the incidence of Rota virus infection among children in Al-Asiel Hospital, Al-Bayda City, Libya, from March 2021 to January 2022. Stool specimens from children under 8 years of age with gastroenteritis were examined using a qualitative immunochromatographic assay for rapid detection of Rota virus antigens. There were 100 samples from patients aged between 4 months − 8 years. The data analysis showed that 61% of diarrheal cases were positive for Rota virus antigens. Rota virus infections were mostly found in children between 5 and 11 months of age, as well as in children between one and 8 years of age. Most cases occurred in the winter. Laboratory testing should be undertaken to identify Rota virus in samples from sick children and babies, as the diagnosis of cases that was followed in most pediatric departments in medical clinics was based on clinical symptoms rather than an accurate laboratory diagnosis

References

1. E. J. Anderson, S. G. Weber, Rota virus infection in adults. The Lancet infectious diseases 4, 91 (2004).

2. A. Chissaque, M. Cassocera, C. Gasparinho, J. S. Langa, A. F. Bauhofer, J. J. Chilaúle, S. S. Boene. Rota virus A infection in children under five years old with a double health problem: undernutrition and diarrhoea–a cross-sectional study in four provinces of Mozambique. BMC Infectious Diseases 21, 1 (2021).

3. S. Crawford, S. Ramani, J. E. Tate, U. D. Parashar, L. Svensson, M. Hagbom, G. Kang. Rota virus infection. Nature reviews. Disease primers. 3: 17083, (2017).

4. C. Muendo, A. Laving, R. Kumar, B. Osano, T. Egondi, P. Njuguna. Prevalence of Rota virus infection among children with acute diarrhoea after Rota virus vaccine introduction in Kenya, a hospital cross-sectional study. BMC pediatrics 18, 1 (2018).

5. A. H. Ali, H. A. K. Saad, M. B. A. Abdalrahem, M. N. M. Hamad, Seroprevalence of Rota virus among Selected Group of Sudanese Children. SAR J Pathol Microbiol 3, 1 (2022).

6. Z. Dian, Y. Sun, G. Zhang, Y. Xu, X. Fan, X. Yang, Z. Miao. Rota virus-related systemic diseases: clinical manifestation, evidence and pathogenesis. Critical reviews in microbiology 47, 580 (2021).

7. A. A. S. Othma, H. E. Gomaa, M. G. El Anany, E. M. Abdul Rahman, E. M. Hassan, A. M. Abd Elbaky, E. Awadallah. Use of multiplex PCR in diagnosis of childhood acute viral diarrhoea caused by Rota virus, norovirus, astrovirus and adenovirus in Upper Egypt. Egyptian Journal of Medical Human Genetics 23, 1 (2022).

8. S. K. Dey, H. Ushijima, O. Phathammavong, W. Chanit, S. Okitsu, M. Mizuguchi, Y. Ota. Seasonal trend and serotype distribution of Rota virus infection in Japan, 1981–2008. The Pediatric infectious disease journal 29, 166 (2010).

9. F. B. Lestari, S. Vongpunsawad, N. Wanlapakorn, Y. Poovorawan, Rota virus infection in children in Southeast Asia 2008–2018: disease burden, genotype distribution, seasonality, and vaccination. Journal of biomedical science 27, 1 (2020).

10. A. R. Hameed, B. Y. Mohamed, A. D. Abakar, K. S. Ali, The Biological Characteristics of Human Rota virus and Their Relationship to Gastroenteritis, As a Literature Review. Int. J. Sci. Res. in Biological Sciences Vol 8, (2021).

11. C. M. Mbadiko, D. M SN, G. K. Mbuyi, E. Bukaka, R. C. Tshiama, G. N.Bongo. Epidemiological and Clinical Profiles of Acute Diarrhea Due Rota virus or Associated Rota virus and Other Pathogens in Children Aged 0-71 Months Hospitalized at Kalembe-lembe Pediatric Hospital in Kinshasa, Democratic Republic of the Congo. Global Journal of Epidemiology and Infectious Disease, 66 (2021).

12. U. D. Parashar, E. A. S. Nelson, G. Kang, Diagnosis, management, and prevention of Rota virus gastroenteritis in children. Bmj 347, (2013).

13. V. Ghoshal, M. K. Nayak, N. Misra, R. Kumar, N. S. Reddy N. K. Mohakud. Surveillance and molecular characterization of Rota virus strains circulating in Odisha, India after introduction of rotavac. The Indian Journal of Pediatrics 88, 41 (2021)

14. K. Levy, A. E. Hubbard, J. N. Eisenberg, Seasonality of Rota virus disease in the tropics: a systematic review and meta-analysis. International journal of epidemiology 38, 1487 (2009).