Investigation into Causes of Allergic Diseases Using Quantitative Measurement of Allergen-Specific Ige in Serum in Al- Bayda, Libya

• Abdulsalam Elfowiris

  Department of Pharmacology and Toxicology, Faculty of Pharmacy, Omar Al-Mukhtar University, Al-Bayda- Libya

  Author

• Monier Sharif

  Department of Pathology and Anatomy, Faculty of Veterinary, Omar Al-Mukhtar University, Al-Bayda- Libya

  Author

• Salma Bianco

  Ministry of health, Al-Bayda- Libya

  Author

Allergy is a complex condition that results from different causative factors and different kinds of reactions, which caused by vibrant interactions ranged from genetic predisposition, environmental factors, food reaction, animals, insects, to a dysfunctional immune system. A public concern has grown in response to the increasing prevalence of allergy and related atopic conditions. Although the underlying mechanism of the true causes of allergy is complicated due to insufficient data and variable methodologies, Immunoglobulin E (Ig E) is commonly accepted as a specific index for allergic diseases among many indices used to test allergy. The aim of the study was to perform analysis of food allergens, inhalatory allergens, and other allergens types in patients diagnosed with an allergy by testing specific IgE to understand the risk factors, prediction, preventing, and determine the treatment. The results showed that specific IgE serum levels are significantly higher in patients sensitized to D. pteronyssinus and D. farinae allergens. However, more data and studies are needed to investigate the local allergens that cause allergy.

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Hannaway, P. J., & Roundy, C. (1997). Distribution of Dermatophagoides spp., D. farinae and D. pteronyssinus, antigen in homes of patients with asthma in eastern Massachusetts. Allergy Asthma Proc, 18(3), 177-180.

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Jang, W. R., Nahm, C. H., Kim, J. H., Lim, D. H., Jang, T. Y., Moon, Y. S., & Kim, J. J. (2009). [Allergen specific IgE measurement with Polycheck Allergy: comparison of three multiple allergen simultaneous tests]. Korean J Lab Med, 29(5), 465-472.

Jhamnani, R. D., Levin, S., Rasooly, M., Stone, K. D., Milner, J. D., Nelson, C., Frischmeyer-Guerrerio, P. A. (2018). Impact of food allergy on the growth of children with moderate-severe atopic dermatitis. J Allergy Clin Immunol, 141(4), 1526-1529 e1524.

Mastrorilli, C., Caffarelli, C., & Hoffmann-Sommergruber, K. (2017). Food allergy and atopic dermatitis: Prediction, progression, and prevention. Pediatr Allergy Immunol, 28(8), 831-840.

Michael, W. (2011). [Food intolerance or allergy?]. MMW Fortschr Med, 153(26-28), 38-42; quiz 43.

Park, S., Lee, E. H., & Kho, Y. (2016). The association of asthma, total IgE, and blood lead and cadmium levels. J Allergy Clin Immunol, 138(6), 1701-1703 e1706.

Porteous, T., Wyke, S., Smith, S., Bond, C., Francis, J., Lee, A. J., Smith, L. (2013). 'Help for Hay Fever', a goal-focused intervention for people with intermittent allergic rhinitis, delivered in Scottish community pharmacies: study protocol for a pilot cluster randomized controlled trial. Trials, 14, 217.

Sicherer, S. H., & Sampson, H. A. (2018). Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol, 141(1), 41-58.

Traidl-Hoffmann, C., Kasche, A., Menzel, A., Jakob, T., Thiel, M., Ring, J., & Behrendt, H. (2003). Impact of pollen on human health: more than allergen carriers? Int Arch Allergy Immunol, 131(1), 1-13.

Zhao, J., Jia, S., Xie, P., Arenas, G. A., Galiano, R. D., Hong, S. J., & Mustoe, T. A. (2017). Topical application of Dermatophagoides farinae or oxazolone induces symptoms of atopic dermatitis in the rabbit ear. Arch Dermatol Res, 309(7), 567-578.

Zukiewicz-Sobczak, W. A., Wroblewska, P., Adamczuk, P., & Kopczynski, P. (2013). Causes, symptoms and prevention of food allergy. Postepy Dermatol Alergol, 30(2), 113-116.

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