The Effect of Oxytocin on the Body Weight of Male Rabbits
- Authors
-
-
Areej A. Mohammed
Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, Al-Bayda, LibyaAuthor -
Aisha F. Bonaama
Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, Al-Bayda, LibyaAuthor -
Souad A. M. Moftah
Department of Zoology, Faculty of Arts and Science, Benghazi University, Almarj, LibyaAuthor -
Ameerah T. Ramadhan
Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, Al-Bayda, LibyaAuthor -
Abdulsalam M. A. Bolhaj
Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, Al-Bayda, LibyaAuthor -
Somya A. Aregeb
Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, Al-Bayda, LibyaAuthor -
Mohamed A. ElMabrouk
Department of Marine Science, Faculty of Science, Omar Al-Mukhtar University, Al-Bayda, LibyaAuthor
-
- Keywords:
- Oxytocin, Body Weight, Rabbits, Food Consumption
- Abstract
-
This study was carried out to investigate the effect of two different doses of oxytocin on weight. Adult male rabbits (15) were weighed and provided with food twice daily for 3 weeks to determine the amount of food consumed daily and the time spent feeding by each rabbit. After 3 weeks the rabbits were weighed and divided randomly into 3groups: the control group, the low dose group, and the high dose group. The animals were injected daily for 3 weeks. During that time the amount of food consumed and the time spent feeding in both periods were determined. After the end of the treatment period the rabbits were weighed, and sacrificed. The results of this study showed that before treatment the rabbits consumed more food in the evening period than they did in the afternoon period. The mean time spent feeding in the evening period was slightly higher than that spent in the afternoon period; however, this difference was not statistically significant. After treatment, there was still significant difference between the means of the consumed food in the afternoon and the evening period for the control group. The mean amounts of food consumed in both periods by the treated groups were slightly reduced, but this reduction was not statistically significant. Furthermore, the mean time spent feeding in the evening period was slightly higher than that of the afternoon period for the 3 groups; however, these differences were not significant. The mean weight of the control group was slightly increased after treatment with the hormone; and the mean weights of the treated groups were slightly reduced after treatment. However, changes in body weighs were not statistically significant.
- Downloads
-
Download data is not yet available.
- References
-
Amico, J. A., Vollmer, R. R., Cai, H.-m., Miedlar, J. A., & Rinaman, L. (2005). Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289(6), R1798-R1806.
Apter-Levy, Y., Feldman, M., Vakart, A., Ebstein, R. P., & Feldman, R. (2013). Impact of maternal depression across the first 6 years of life on the child’s mental health, social engagement, and empathy: the moderating role of oxytocin. American Journal of Psychiatry, 170(10), 1161-1168.
Arletti, R., Benelli, A., & Bertolini, A. (1989). Influence of oxytocin on feeding behavior in the rat. Peptides, 10(1), 89-93.
Arletti, R., Benelli, A., & Bertolini, A. (1990). Oxytocin inhibits food and fluid intake in rats. Physiology & behavior, 48(6), 825-830.
Blanks, A. M., & Thornton, S. (2003). The role of oxytocin in parturition. BJOG: An International Journal of Obstetrics & Gynaecology, 110, 46-51.
Blevins, J. E., Graham, J. L., Morton, G. J., Bales, K. L., Schwartz, M. W., Baskin, D. G., & Havel, P. J. (2014). Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 308(5), R431-R438.
Blevins, J. E., Thompson, B. W., Anekonda, V. T., Ho, J. M., Graham, J. L., Roberts, Z. S., Hwang, B. H., Ogimoto, K., Wolden-Hanson, T., & Nelson, J. (2016). Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 310(7), R640-R658.
Blouet, C., Jo, Y.-H., Li, X., & Schwartz, G. J. (2009). Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus–brainstem circuit. Journal of Neuroscience, 29(26), 8302-8311.
Breton, C., Di Scala-Guenot, D., & Zingg, H. (2001). Oxytocin receptor gene expression in rat mammary gland: structural characterization and regulation. Journal of molecular endocrinology, 27(2), 175-190.
Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., & Bussier, A. (2011). Mechanisms of the Anti-Obesity Effects of Oxytocin in Diet-Induced Obese.
Gimpl, G., & Fahrenholz, F. (2001). The oxytocin receptor system: structure, function, and regulation. Physiological reviews, 81(2), 629-683.
Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., & Zinn, A. R. (2008). Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Molecular endocrinology, 22(7), 1723-1734.
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015). Oxytocin reduces caloric intake in men. Obesity, 23(5), 950-956.
Li, L., Kong, X., Liu, H., & Liu, C. (2007). Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits. Neurogastroenterology & Motility, 19(10), 839-844.
Lokrantz, C.-M., Uvnäs-Moberg, K., & Kaplan, J. M. (1997). Effects of central oxytocin administration on intraoral intake of glucose in deprived and nondeprived rats. Physiology & behavior, 62(2), 347-352.
Luck, M., & Jungclas, B. (1987). Catecholamines and ascorbic acid as stimulators of bovine ovarian oxytocin secretion. Journal of endocrinology, 114(3), 423-430.
MacDonald, K., & MacDonald, T. M. (2010). The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans. Harvard review of psychiatry, 18(1), 1-21.
Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T. (2011). Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY), 3(12), 1169.
Miedlar, J. A., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007). Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 293(3), R1063-R1068.
Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012). Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. American Journal of Physiology-Endocrinology and Metabolism, 302(1), E134-E144.
Mullis, K., Kay, K., & Williams, D. L. (2013). Oxytocin action in the ventral tegmental area affects sucrose intake. Brain research, 1513, 85-91.
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991). Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats. Peptides, 12(1), 113-118.
Ott, V., Finlayson, G., Lehnert, H., Heitmann, B., Heinrichs, M., Born, J., & Hallschmid, M. (2013). Oxytocin reduces reward-driven food intake in humans. Diabetes, 62(10), 3418-3425.
Pischon, T., Boeing, H., Hoffmann, K., Bergmann, M., Schulze, M. B., Overvad, K., Van der Schouw, Y., Spencer, E., Moons, K., & Tjønneland, A. (2008). General and abdominal adiposity and risk of death in Europe. New England Journal of Medicine, 359(20), 2105-2120.
Rinaman, L., & Rothe, E. E. (2002). GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 283(1), R99-R106.
Sclafani, A., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007). Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 292(5), R1828-R1833.
Thienel, M., Fritsche, A., Heinrichs, M., Peter, A., Ewers, M., Lehnert, H., Born, J., & Hallschmid, M. (2016). Oxytocin’s inhibitory effect on food intake is stronger in obese than normal-weight men. International journal of obesity, 40(11), 1707-1714.
Yamashita, M., Takayanagi, Y., Yoshida, M., Nishimori, K., Kusama, M., & Onaka, T. (2013). Involvement of prolactin‐releasing peptide in the activation of oxytocin neurones in response to food intake. Journal of neuroendocrinology, 25(5), 455-465.
Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q., & Cai, D. (2011). Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron, 69(3), 523-535.
Zhang, G., & Cai, D. (2011). Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. American Journal of Physiology-Endocrinology and Metabolism, 301(5), E1004-E1012.
Zhang, H., Wu, C., Chen, Q., Chen, X., Xu, Z., Wu, J., & Cai, D. (2013). Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLOS ONE, 8(5), e61477.
- Downloads
- Published
- 2021-12-31
- Issue
- Vol. 36 No. 4 (2021)
- Section
- Articles
- License
-
Copyright (c) 2021 Areej A. Mohammed, Aisha F. Bonaama, Souad A. M. Moftah, Ameerah T. Ramadhan, Abdulsalam M. A. Bolhaj, Somya A. Aregeb, Mohamed A. ElMabrouk

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright of the articles Published by Almukhtar Journal of Science (MJSc) is retained by the author(s), who grant MJSc a license to publish the article. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors and cite MJSc as the original publisher. Also, they accept the article remains published by the MJSc website (except in the occasion of a retraction of the article).
How to Cite
Similar Articles
- Majdi A. Kairalla , Abdalhakim A. Aburas , kurmuan A. Omar, Effect of Probiotic, Prebiotic, Synbiotic and Medicinal Plants on Productive Performance of Broilers Fed on Different Levels of Protein , Al-Mukhtar Journal of Sciences: Vol. 33 No. 4 (2018)
- Galal M. Elmanfe, Osama E. Khreit , Omukalthum A. Abduljalil , Najah M. Abbas , Determination of Para-Phenylenediamine (PPD) in Henna Samples Collected from Libyan Local Markets Using HPLC , Al-Mukhtar Journal of Sciences: Vol. 37 No. 1 (2022)
- Khawila S. O. Bubaker, Survey on common causative agents of dermatophytosis in El-Beida Libya , Al-Mukhtar Journal of Sciences: Vol. 34 No. 3 (2019)
- Abdel-Wahab Ramadan Obaia, Heat Losses Estimation And Heating Required To Cucumber Planted In Greenhouses Under AL-Gabal AL-Akhdar Region Conditions , Al-Mukhtar Journal of Sciences: Vol. 27 No. 1 (2012)
- Azza s. Abdelkafe, Muftah A. Nasib, Dermatophytosis in Al-Gabal Al-Akhader , Al-Mukhtar Journal of Sciences: Vol. 27 No. 1 (2012)
- Abdelnaser Othman Busba, Jebril Elabidi, Samia M Al Ojaly, Prevalence of Urinary Tract Infection in Children Admitted to Benghazi Children’s Hospital , Al-Mukhtar Journal of Sciences: Vol. 33 No. 4 (2018)
- Mariam Saleh Boufatoum, Imran Abu Saleh Abu Bakri , Effect of some Plant Users on the White Garden Parakeet , Al-Mukhtar Journal of Sciences: Vol. 28 No. 2 (2013)
- Fouad A Zein Elarab, Abdassalam B Aldaikh, Green's Function Method for Ordinary Differential Equations , Al-Mukhtar Journal of Sciences: Vol. 28 No. 1 (2013)
- Idress H. Attitalla, Effects of Azospirillum lipoferum strain isolated from Al Jabal Al Akhdar region and wheat straw on some physiological properties and nitrogen content of Triticum aestivum cultivars , Al-Mukhtar Journal of Sciences: Vol. 26 No. 1 (2011)
- Marim salah Bou fatoum, Survey of some land snails in Jabel El-Akhdar area, Libya and the damage caused by Theba pisana To Brassica olerace , Al-Mukhtar Journal of Sciences: Vol. 26 No. 1 (2011)
You may also start an advanced similarity search for this article.











