Effects of polyunsaturated fatty acids on hepatic lipid metabolism

• Mohamad Ali Kassem

  Faculty of Pharmacy, Faculty of Pharmacy, Omar El-Mukhtar El-beida, Libya

  Author

Effects of dietary treatment of male albino rats with eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on hepatic mitochondrial lipid metabolism have been investigated. Mitochondria isolated from rats given these treatments were shown to have increased ability to respire on acyl-CoA esters in the presence of malonate. In rats treated with EPA in the fed state, the amount of EPA incorporated into mitochondrial lipids wase markedly more increased as compared to control rats. A hypolipidaemic effect of dietry EPA was only observed when the fatty acid was given to fed rats, may result from diminished synthesis and export of very-low density lipoprotein from the liver.In line with this argument the hepatic level of triacylglycerol was found not be increased in these rats, and this may therefore reflect increased hepatic B-oxidation. Diminished lipolysis may also occur, as dietary EPA can inhibit lipolysis in mice.  Rats treated with EPA in the fasted state, in contrast, exhibited hypoglycaemia. When malonate in the incubations was replaced with malate, mitochondria from treated animals were found to exhibit diminished rates of respiration on polyunsaturated acyl-CoA esters. This phenomenon could not attributed to changes in activity of carnitine palmitoyltransferase1. No significant differences  between the effects of EPA and DHA.

Folch,J., Less.M. and Sloane.Stanley,G.H. (1957) J. Biol. Chem. 226, 497-509.

Harris, W. S. (1995) J. Lipid Res. 30, 785-807.

Henley, D. C. and Berry, M. N. (1995) Biochem. Biophys. Acta 1175, 269-276.

Ide, T., Murata, M. and Sugano, M. (1996) J. Lipid Res. 37, 448-463.

Jiang, C., Skinner, K., Anderson. R. A. and Rudel, L. L. (2000) Curr. Opin. Lipidol. 10, 89- 95.

Michael, W. P., Garrison, R. J., Wilson, P. W. and Kannel, W. B. (2005) Am. J. Clin. Nutr. 31, 1340-1346.

Schmidt, E. B., Kristensen, S. D., Catrina, R. and Illinqworth, D. R. (1993) Atherosclerosis 103, 107-121.

Shirai, S., Wu, P. and Osmundsen, H. (2000) Biochem. J. 305, 591-595.

Van Bitter Swijk and Houssa , G. (2000) J. Lipid Res. 36, 469- 474.

Willumsen, N., Vaagenes, H., Lie, O.., Rustan, A. C. and Berge, K. (1996) Lipids 31, 579- 592.

Xiangnan, S. H., Fisher, A. and Marsh, J. B. (2005) Eur. J. Biochem. 196, 499- 507.

Xiaozhong, V. A., Corstorphine, C. G. and Kolodziej, M. P. (2006) Biochem. J. 263, 89-95.

• PDF (Arabic)

Copyright (c) 2022 محمد علي قاسم

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright of the articles Published by Almukhtar Journal of Science (MJSc) is retained by the author(s), who grant MJSc a license to publish the article. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors and cite MJSc as the original publisher. Also, they accept the article remains published by the MJSc website (except in the occasion of a retraction of the article).