Evaluating Serum Ferritin as a biochemical marker of  Oxidative Stress in Type 2 Diabetes Mellitus

• Manal Jamal Diryaq

  Department of Pharmacology and Toxicology, Omar Al-Mukhtar University, Libya

  Author

• Abdulsalam A. Elfowiris

  Biomedical Sciences, College of Basic Sciences, Libyan Academy for Postgraduate Studies, Libya

  Author

Elevated blood glucose levels and insulin resistance are two main features of Type 2 Diabetes Mellitus. Arising evidence suggests a mutual influence between iron overload and oxidative stress that impair insulin signaling, damage β pancreatic cells and promotes inflammation thereby contributing significantly to the progression and complications of T2DM, This cross sectional study aims to determine the effect of serum ferritin on T2DM and its correlation with oxidative stress, involving 80 participants, divided equally into diabetic and control group, anthropometric measurements as BMI  and biochemical analysis including fasting blood glucose (F.B.G), glycated hemoglobin (HbA1c), insulin level, HOMA IR, serum ferritin and TBARS level were evaluated. The results showed a significant elevation in BMI, F.B.G., HbA1c, insulin levels, HOMA-IR, ferritin levels, and TBARS levels in the diabetic group (p < 0.05). Ferritin levels showed a moderate positive correlation with HOMA IR (r = 0.63) and FBG (r = 0.60). A weaker correlation was observed with HbA1c (r = 0.4) and oxidative stress markers (r = 0.4). These findings suggest that elevated ferritin may serve as a potential biomarker for insulin resistance and metabolic imbalance in type 2 diabetes mellitus (T2DM), and can also be a biochemical indicator of oxidative stress levels.

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