Clinical Changes Evaluations in Amphotericin B Induced Osteoarthritis in Canine Models

Rehab Hamad; Asma Elmabrok; Hassan Hamad; Khaled Hussin

doi:10.54172/0hdbtq27

Authors

Rehab Hamad Department of Clinical Veterinary Medical Sciences, Faculty of Veterinary Medicine, Omar Al- Mukhtar University, Al-Beyda, Libya Author
Asma Elmabrok Department of Botany, Faculty of Science, Darna University, Darna, Libya Author
Hassan Hamad Department of Pharmacy, Higher Institute of Medical Sciences and Technologies-El-Marj, Libya Author
Khaled Hussin Department of Clinical Veterinary Medical Sciences, Faculty of Veterinary Medicine, Omar Al- Mukhtar University, Al-Beyda, Libya Author

DOI:

https://doi.org/10.54172/0hdbtq27

Keywords:

Dogs, Stifle joint, Amphotericin B, Osteoarthritis, Canine Models

Abstract

The experimental model of osteoarthritis (OA) was replicated in Six dogs induced osteoarthritis by intra-articular injection with amphotericin B (AB) in the left stifle joints. Right joints served as control. Medical status and certain goniometric parameters were tracked prior to the initiation of AB and on the 30th, 60th and 90th days after injection. The findings showed compellingly that the OA model used by the experimental chemical effectively replicated the disease in the stifle joints in dogs and showed a progressive disease progression, just as it does in the reported cases of arthritis that naturally affects dogs depending on the time of inflammation. Medical indications studied were associated with the seriousness of the disease.

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