Impact of a single dose of Doramectin on Hematological and Biochemical parameters in goats

Abdel-Wahed Mashalla

doi:10.54172/ndxmp181

Authors

Abdel-Wahed Mashalla Pharmacology, Toxicology and Forensic Medicine Department, Faculty of Veterinary Medicine, Omar Al- Mukhtar University, Al Beyda . Libya. Author

DOI:

https://doi.org/10.54172/ndxmp181

Keywords:

Doramectin, hematological, some biochemical, parameters

Abstract

The present study was conducted to evaluate the effect of a single dose of doramectin a number of hematological and biochemical parameters in goats. Twenty goats were equally divided into two groups, each of 10 goats. The control group was kept without any medication. While the treated group received a single dose of doramectin at a dose level of 1 ml per 33kg of body weight subcutaneously after two and four weeks form the beginning of drug administration blood samples were collected via the jugular vein from the control and treated groups. The results demonstrated that red blood cell (RBC) counts, hemoglobin concentration (Hb %) and White blood cell (WBC) counts were significantly (p<0.05) decreased in treated groups at weeks 2^nd and 4^th weeks as compared to the control group. While serum levels of albumin were significantly (p<0.05) increased in treated goats in comparison with the control at 2^nd and 4^th weeks of the experiment. However, there were non-significant changes in packed cell volume (PCV%), globulin and total protein levels in the treated group as compared with the control at all the experiment period. Thus, the therapeutic dose of doramectin can induce minor changes in some blood parameters in goats. packed cell volume (PCV%) was changed with non-significant at week 2 and week 4 in the treated group compression to the control group. White blood cell (WBC) counts decreased in all groups treated from the onset to the end change in both the time treated goats at 2 and 4 weeks compared with the control group. Thus, the therapeutic dose of doramectin can induce minor changes in some blood parameters in goats.

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